March 13


Lack of Vitamin C Linked to Obesity, Insulin Resistance, and Addiction to Cigarettes?

By Gabriela

March 13, 2024

Those who have to deal with chronic conditions usually have higher nutrient demands than a completely healthy person would. These nutrients are considered conditionally essential.

There is either oxidative stress, underlying inflammation, a disruption in one’s metabolic processes, or, for that matter, an inability of sorts to meet the metabolic demands with the nutrient reserves one currently has.

Nutrients published a study a while ago, in which they reported that those patients who were pre-diabetic, smokers, or with type II diabetes, have lower plasma within their vitamin C levels. This is logical, as most experts have linked chronic inflammation with insulin resistance.

So, naturally, there will be higher vitamin C requirements, to mitigate oxidative stress. But it’s not like this is the only contributing factor. Other factors that may lead to this are the excretion of vitamin C in individuals with microalbuminuria.

What the Research Says

Or perhaps the competition for vitamin C and glucose in the cells. This new study involved 89 participants, all over the age of 18. Some had either pre-diabetes, normal fasting glucose, or type 2.

Between these groups, researchers did not witness any significant differences when it comes to the macronutrient dietary vitamin C intake. However, in the participants diagnosed with type 2, the plasma vitamin C concentrations were noticeably lower.

Additionally, in the diabetes group and the pre-diabetes group, vitamin C deficiency was at a much higher percentage. As a result, researchers demonstrated that smoking history, BMI, intake of dietary vitamin C, and fasting glucose are all significant markers of vitamin C plasma concentrations.

This indicates that those who have a history of pre-diabetes, smoking, obesity, and diabetes have indeed greater requirements for vitamin C.

This means such patients should consider vitamin C supplementation, to support their general health as well as prevent any further complications.

Certain previous research suggested that about 200 grams of vitamin C a day can cause a significant reduction in one’s glucose concentrations.

But the fact remains that the exact nutrient dosage can vary from individual to individual when it comes to maintaining the best possible health.

Environmental exposures coupled with lifestyle choices and filtered through a genetic predisposition represent fundamental factors.

This is when it comes to the occurrence and development of the disease. That’s why the careful investigation of all these factors is key to an effective treatment approach.

Some Further Information

On the subject of insulin resistance, other vital nutrients include inositol and vitamin E. The American Journal of Clinical Nutrition published a study back in 2015.

In it, they reported that about 1/3 of Americans who have metabolic syndrome, compared to healthy individuals, cannot effectively absorb dietary vitamin E. And yet even more research has witnessed that a deficiency in inositol is rather common in those with insulin resistance.

This is characterized by an inability (or reduced ability) to metabolize, process, and successfully use inositol from one’s meals. This indeed represents a distinctive characteristic of insulin resistance.

The result may be that such individuals may not fully meet their nutritional requirements. Especially not by a simple change in one’s diet. In such cases, inositol should certainly be considered a conditionally essential nutrient for these patients.



  • Gabriela

    Co-Founder & Editor-in-Chief of Diabetes Health Page, Fitness trainer and instructor has dedicated her career to educating and informing people for over 10 years. As one of the most passionate diabetes advocates, Gabi has worked tirelessly to ensure that those people receive the education and support they need to properly manage their diabetes and achieve their health, fitness and weight loss goals.

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