January 28


Insulin Resistance – What it is and What to Do About it

By Gabriela

January 28, 2021

There is a divide between the conventional definition of type II diabetes and the ancestral one.

For example, according to science, type II diabetes, as well as prediabetes, works almost as a synonym for high blood sugar, whereas the ancestral definition has the approach of a perfect body being in the incorrect and unfitting environment.

These two theories, in the end, have different clinical results.

Hyperglycemia Diagnosis

High blood sugar almost comes as a synonym for prediabetes and diabetes type II. The diagnosis process consists of measuring the levels of blood sugar.

Fasting Glucose – Hemoglobin

  • Glucose: Pre-meal and exercise;
  • Optimal: 75 to 95 mg or dL (from 4.2 to 5.3 mmol to L);
  • Low: less than 75 mg or dL (from less than 4.2 mmol or L);
  • Borderline-high: 96 to 100 mg or dL (from 5.3 to 5.6 mmol or L);
  • High, but not “yet” diagnosed: 101 to 125 mg or dL (from 5.7 to 7.0 mmol or L);
  • Diagnosis: above 125 mg or dL (from above 7.0 mmol or L).

Hemoglobin A1C: A Percentage of Hemoglobin

  • Normal: 4.5 to 5.7% (from 26 to 39 mmol or mol);
  • Significant insulin resistance: 5.8 to 6.4% (from 40 to 46 mmol or mol);
  • Diabetes: above 6.4% (from above 46 mmol or mol).

The levels of glucose in the system are usually elevated in the morning. This is called “the dawn phenomenon” – the insulin levels are lower than the glucagon made in the morning. High levels of glucose in the system imply but do not indicate insulin resistance.

Since this is the case, this is a list of the triggers of hyperglycemia in the morning that don’t blame IR:

  • Low-quality sleep: Glucose is higher in the morning because of chatecholamines1;
  • Anxiety: Too much adrenaline triggers the dawn phenomenon;
  • Working out: This can inspire the production of glycogen, which brings up high blood glucose.

Hyperglycemia: How to Look After

The treatment of hyperglycemia is more than evident. Right now we know of two pharmaceutical methods to showcase hypoglycemic effects:

1. Engaging in the production of glucose – Metformin, also known as the main medication used in this category. It stops the production of glucose from the muscles and liver.

2. Increase the insulin intake and production. This can be done with injection/inhalation, as well as using compounds that trigger and stimulate the production or insulin secretion. Glipizide or glyburide and sulfonylureas are the main meds that trigger the production of insulin.

The insulin’s duty is to keep glucose inside the storage disposals of our bodies like the liver, muscles, and adipose.

This newcomer method that reduces glucose levels stimulates therapeutic glucosuria. These sodium inhibitors are considerations for type II diabetes and are very rarely used, mostly because of unforeseen problems.

Metformin and biguanides remain first in line for treatment, however. Biguanides don’t raise insulin levels. It has two main actions. One is to trigger cells to create more glucose, and the second is to stop the release of glucose from our muscles as well as the liver.

Our bodies work in a debt-repay type of way, therefore releasing glucose from the storage really doesn’t do it any good. Metformin interferes with the performance of an exercise.

That is why type II diabetes-diagnosed individuals are advised to work out without wearing themselves out because it increases heart rate and causes great fatigue.

Sulfonylureas increase the release of insulin from the pancreas. If a professional were to prescribe meds that will help stimulate the insulin, they need to be aware that high blood sugar comes from inadequate insulin release.

High insulin levels are not something anyone strives to achieve. In fact, it causes heart failure, cancer, and obesity.


Even though botanicals are less successful and don’t really have any groundbreaking results, they’re still a considerable option to incorporate within your treatment.

There are leaf extract, American ginseng, bitter melon, and fenugreek.

Insulin Resistance

What if sometimes the problem with insulin resistance isn’t the high blood sugar? Maybe the hypoglycemic substances are to blame? This can be found by a simple measurement of serum insulin.

Human survival by definition stands for storing calories and going through extreme physical activity. There are about 15 out of 33 genes that are connected to insulin resistance.

Insulin Resistance: Indications

Insulin resistance is related to high glucose levels

  • Low: <3 µIU or mL (less than 18 pmol or L);
  • Optimal: 3 to 8 µIU or mL (18 to 48 pmol or L);
  • High: less than 8 µIU or mL (above 48 pmol or L).

Low insulin: Scientists currently can’t detect insulin less than 2 µIU or mL. If we can’t find any clues that lead to fasting insulin, but if the blood sugar is elevated at the same time, this could lead to type 1 diabetes and should be examined and checked out. However low to normal insulin indicates a healthy and sensitive metabolism.

High insulin: During blood tests, if there’s a sign of elevated levels, then it shows that the person is building fat. High insulin levels usually don’t come up in a thin person. The risk of type II diabetes is suggested by an insulin level above 48 pmol or L.

IR Quantity

People with elevated levels usually go through weight gain, HBP, and an increased risk of cancer development. Changing lifestyle habits will lower the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and decrease the chances of developing more severe diseases.


HOMA-IR / Glucose (mg or dL) / Insulin (µIU or mL)

  • Optimal: 1.0 (0.5 to 1.4);
  • Early IR: above 1.9;
  • Significant IR:  above 2.9.

Lipid Patterns

As the triglyceride levels go up, less cholesterol is made in our body. This condition is known to be called diabetic atherogenic dyslipidemia. When the lipid levels go out of balance, heart diseases tend to follow.

Triglyceride to HDL Ratio

  • Optimal: 0.5 to 1.5;
  • Extra fat storage: from 1.5 to 3.0;
  • Risk of heart issues: above 3.0.

A More Efficient Therapeutic Approach

The two most important factors to improving your health as well as balancing out your blood sugar levels consist of diet and exercise, both terms that need to be addressed and approached separately.

You should consult your physician about what type of exercise and diet to start adopting in your lifestyle. It should be in accordance with your genetics.


Reduced alcohol intake, and taking different kinds of herbs and supplements are what you need in your diet.  A diet low on carbs that contains less than fifty grams of carbs a day is the most recommended eating lifestyle for fighting hyperglycemia.


A perfectly realistic two hours weekly of aerobic workouts is excellent when you’re fighting insulin resistance. The following are four principles when it comes to exercise for people who are insulin-resistant.

  • Always exercise without eating a meal prior before;
  • You should exercise strenuously;
  • Activate the more muscles you can, the better;
  • Put yourself through an exercise that will cause various heart rate numbers throughout the process.

Source NDNR


  • Gabriela

    Co-Founder & Editor-in-Chief of Diabetes Health Page, Fitness trainer and instructor has dedicated her career to educating and informing people for over 10 years. As one of the most passionate diabetes advocates, Gabi has worked tirelessly to ensure that those people receive the education and support they need to properly manage their diabetes and achieve their health, fitness and weight loss goals.

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